Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing,Biomacromolecules

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Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing
Biomacromolecules ( IF 5.5 ) Pub Date : 2017-10-11 00:00:00 , DOI: 10.1021/acs.biomac.7b01180
Qing Li ₁ , Fei Lu _{1,

2} , Guofang Zhou ₁ , Kun Yu ₁ , Bitao Lu ₁ , Yang Xiao ₃ , Fangying Dai _{1,

2} , Dayang Wu _{1,

2} , Guangqian Lan _{1,

2}

Affiliation

Silver inlaid with gold nanoparticles (Au–Ag NPs) prepared by using egg white with an average sized of 10 nm and homogeneous dispersion were tested and presented red fluorescence. Au–Ag NPs were loaded into chitosan as wound dressing (CS–Au–Ag). CS–Au–Ag released silver ions faster, in higher amount, and in a more durable manner than chitosan dressing loaded with silver nanoparticles with the same silver content (CS–Ag), consequently, showing enhanced antibacterial activity. Cytotoxicity tests indicated that CS–Au–Ag showed low cytotoxicity to L929 cells similar to CS–Ag. These data suggest that cytotoxicity, which restricts further application of silver NPs, can be eliminated by decreasing the silver content. CS–Au–Ag presented rich and well-distributed pores, good mechanical properties, and enhanced swelling and retention properties, contributing to keeping the wound moist in the presence of residual egg white. Altogether, our results suggest that CS–Au–Ag greatly promoted wound healing compared to CS–Ag in vivo, demonstrating that CS–Au–Ag presents great potential for wound dressing, promoting wound healing.

中文翻译：

银纳米金/壳聚糖伤口敷料镶嵌可增强抗菌活性和孔隙率，并促进伤口愈合

通过使用平均粒径为10 nm的蛋清和均匀分散液制备的金纳米颗粒（Au–Ag NPs）镶嵌的银进行了测试，并显示了红色荧光。Au-Ag NPs作为伤口敷料（CS-Au-Ag）被装载到壳聚糖中。与负载有相同银含量的银纳米颗粒的壳聚糖敷料（CS-Ag）相比，CS-Au-Ag释放银离子的速度更快，数量更多且更持久。因此，其抗菌活性增强。细胞毒性试验表明，CS-Au-Ag对L929细胞的毒性低，类似于CS-Ag。这些数据表明，可通过降低银含量来消除限制银NP进一步应用的细胞毒性。CS–Au–Ag具有丰富且分布均匀的毛孔，良好的机械性能以及增强的溶胀和保留性能，在残留蛋清的情况下有助于保持伤口湿润。总之，我们的结果表明，与体内CS-Ag相比，CS-Au-Ag大大促进了伤口的愈合，表明CS-Au-Ag在伤口包扎，促进伤口愈合方面具有巨大潜力。

更新日期：2017-10-12

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