Fluorescent Probe DCVJ Shows High Sensitivity for Characterization of Amyloid β-Peptide Early in the Lag Phase,ChemBioChem

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Fluorescent Probe DCVJ Shows High Sensitivity for Characterization of Amyloid β-Peptide Early in the Lag Phase
ChemBioChem ( IF 2.6 ) Pub Date : 2017-10-12 07:09:15 , DOI: 10.1002/cbic.201700387
Sureshbabu Nagarajan _{1,

2} , Lisa J. Lapidus _{1,

3}

Affiliation

The sooner, the better: Whereas existing probes and techniques fail to detect oligomers at high resolution, we show that the fluorescent 9-(dicyano-vinyl)julolidine (DCVJ) binds amyloid β early aggregates. The demonstrated sensitivity of DCVJ to oligomer structure and packing provides us with a suitable probe to detect the early lag phase of amyloid assembly.

中文翻译：

荧光探针DCVJ对滞后阶段早期的淀粉样β肽表征具有很高的灵敏度

越早越好：现有的探针和技术无法以高分辨率检测寡聚体，但我们证明了荧光9-（二氰基-乙烯基）假核苷（DCVJ）与淀粉样β早期聚集体结合。已证明DCVJ对低聚物结构和堆积的敏感性为我们提供了一个合适的探针，用于检测淀粉样蛋白装配的早期滞后阶段。

更新日期：2017-10-12

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