Cushing's disease, pituitary-dependent Cushing's syndrome, is a rare disorder with an incidence in the region of 1–2 cases per million population per year worldwide¹—but is of interest far beyond its rarity: it causes specific problems in diagnosis and can be difficult to treat effectively, but successful therapy can show spectacular clinical transformations. It is most often caused by a small corticotroph tumour, often just a few mm in diameter. In classic cases it presents with florid unmistakable manifestations, although much more subtle cases are increasingly being recognised.

中文翻译：

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库欣氏病的新疗法太甜吗？

库欣病（垂体依赖型库欣综合征）是一种罕见的疾病，在全世界每年每百万人口中发生1-2例左右^1，但它的意义远非其稀有：它引起诊断方面的特定问题，并且可以很难有效治疗，但是成功的治疗可以显示出惊人的临床转变。它最常见是由皮层营养小肿瘤引起的，直径通常只有几毫米。在经典案例中，它呈现出无懈可击的丰富表现，尽管越来越多的微妙案例被人们所认识。