Viral infections are a major global health threat. Over the last 50 years, significant efforts have been devoted to the development of antiviral drugs and great success has been achieved for some viruses. However, other virus infections, such as epidemic influenza, still spread globally and new threats continue to arise from emerging and re-emerging viruses and drug-resistant viruses. In this review, the contributions of microbial products isolated in Institute of Microbial Chemistry for antiviral research are summarized. In addition, the current state of development of antiviral drugs that target influenza virus and hepatitis B virus, and the future prospects for antivirals from natural products are described and discussed.The Journal of Antibiotics advance online publication, 11 October 2017; doi:10.1038/ja.2017.115.

中文翻译：

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微生物产品抗病毒药物的现状和未来前景。


病毒感染是全球主要的健康威胁。过去50年来，人们在抗病毒药物的开发上付出了巨大的努力，并在某些病毒上取得了巨大的成功。然而，流行性流感等其他病毒感染仍在全球范围内传播，新出现和重新出现的病毒以及耐药病毒不断产生新的威胁。本文综述了微生物化学研究所分离的微生物产品在抗病毒研究方面的贡献。此外，还描述和讨论了针对流感病毒和乙型肝炎病毒的抗病毒药物的开发现状，以及天然产物抗病毒药物的未来前景。《抗生素杂志》提前在线出版，2017 年 10 月 11 日； doi：10.1038/ja.2017.115。