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Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2018-Feb-01 , DOI: 10.1038/ja.2017.116
Philip C Hogan , Chi-Li Chen , Kristen M Mulvihill , Jonathan F Lawrence , Eric Moorhead , Jens Rickmeier , Andrew G Myers

Key building blocks for the production of fully synthetic macrolides have been scaled-up in first time pilot plant and kilo-lab campaigns. These building blocks have supported the discovery of new macrolide antibiotics as well as ongoing preclinical studies.

中文翻译:

大规模制备用于生产完全合成的大环内酯类抗生素的关键构件。

在首次试点工厂和千实验室试验活动中,已扩大了生产全合成大环内酯类化合物的关键组成部分。这些组成部分支持了新的大环内酯类抗生素的发现以及正在进行的临床前研究。
更新日期:2017-10-11
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