Long non-coding RNAs (lncRNAs) have emerged as key epigenetic regulators that govern gene expression and influence multiple biological processes. Accumulating evidence demonstrates that lncRNAs have critical roles in immune cell development and function. In this Review, the molecular mechanisms of gene expression regulation by lncRNAs are described and current knowledge of the role of lncRNAs in immune regulation and inflammation are presented, highlighting strategies for defining the roles of lncRNAs in the pathogenesis of multiple rheumatic diseases. Finally, research progress in understanding the role of lncRNAs in rheumatic diseases is discussed.

中文翻译：

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长非编码RNA在风湿性疾病中的作用

长的非编码RNA（lncRNA）已成为控制基因表达并影响多种生物学过程的关键表观遗传调控因子。越来越多的证据表明，lncRNA在免疫细胞的发育和功能中起着至关重要的作用。在这篇综述中，描述了lncRNAs基因表达调控的分子机制，并介绍了有关lncRNAs在免疫调控和炎症中作用的最新知识，重点介绍了定义lncRNAs在多种风湿性疾病发病机理中的作用的策略。最后，讨论了在了解lncRNAs在风湿性疾病中的作用的研究进展。