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Bisoxazolomycin A: a new natural product from 'Streptomyces subflavus subsp. irumaensis' AM-3603.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2017-Dec-01 , DOI: 10.1038/ja.2017.113
Wilaiwan Koomsiri , Yuki Inahashi , Tōru Kimura , Kazuro Shiomi , Yōko Takahashi , Satoshi Ōmura , Arinthip Thamchaipenet , Takuji Nakashima

Bisoxazolomycin (1), oxazolomycin A2 (2) and oxazolomycin A (3) were identified by physicochemical screening approach from a culture broth of 'Streptomyces subflavus subsp. irumaensis' AM-3603. Compound 2 is a hydrolyzed analog of 3 at the β-lactone ring, and 1 is a new dimeric analog of 2. Compounds 1 and 2 exhibited less potent antibacterial activity and cytotoxicity than 3, which might be due to lack of the β-lactone ring.

中文翻译:

Bisoxazolomycin A:来自'Streptomyces subflavus subsp。的新天然产物。irumaensis'AM-3603。

通过物理化学筛选方法从'黄链霉菌亚种(Streptomyces subflavus subsp。)的培养液中鉴定了双恶唑球霉素(1),恶唑球霉素A2(2)和恶唑球霉素A(3)。irumaensis'AM-3603。化合物2是β-内酯环上3的水解类似物,而1是2的新二聚体类似物。化合物1和2的有效抗菌活性和细胞毒性均低于3,这可能是由于缺乏β-内酯引起的。戒指。
更新日期:2017-10-11
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