Bisoxazolomycin (1), oxazolomycin A2 (2) and oxazolomycin A (3) were identified by physicochemical screening approach from a culture broth of 'Streptomyces subflavus subsp. irumaensis' AM-3603. Compound 2 is a hydrolyzed analog of 3 at the β-lactone ring, and 1 is a new dimeric analog of 2. Compounds 1 and 2 exhibited less potent antibacterial activity and cytotoxicity than 3, which might be due to lack of the β-lactone ring.

中文翻译：

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Bisoxazolomycin A：来自'Streptomyces subflavus subsp。的新天然产物。irumaensis'AM-3603。

通过物理化学筛选方法从'黄链霉菌亚种（Streptomyces subflavus subsp。）的培养液中鉴定了双恶唑球霉素（1），恶唑球霉素A2（2）和恶唑球霉素A（3）。irumaensis'AM-3603。化合物2是β-内酯环上3的水解类似物，而1是2的新二聚体类似物。化合物1和2的有效抗菌活性和细胞毒性均低于3，这可能是由于缺乏β-内酯引起的。戒指。