Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery,ACS Macro Letters

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Compact Vesicles Self-Assembled from Binary Graft Copolymers with High Hydrophilic Fraction for Potential Drug/Protein Delivery
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-10-10 00:00:00 , DOI: 10.1021/acsmacrolett.7b00549
Yupeng Wang _{1,

2} , Lina Wang _{1,

3} , Bin Li ₄ , Yanxiang Cheng ₁ , Dongfang Zhou ₁ , Xuesi Chen ₁ , Xiabin Jing ₁ , Yubin Huang ₁

Affiliation

Hollow vesicles self-assembled from amphiphilic copolymers are of great interest in biomedicine field as drug and protein carriers. Efficient preparation of polymeric vesicles with high stability in vivo is highly desirable. Herein, a novel cooperative self-assembly of two graft copolymers (GCPs) with reversed hydrophilic–hydrophobic segments is investigated to achieve morphology control for biomedical application. Interestingly, nanosized vesicles are obtained for the binary system with relatively high hydrophilic fraction (f_hydrophilic, ∼60%), contrary to what is found in its single-component counterpart. The cooperative self-assembly endowed the hybrid vesicles with excellent resistance to protein adsorption, prolonged blood circulation time, as well as low leakage of hydrophilic drugs/proteins. Furthermore, the biological activity of the protein is well preserved inside the cooperative vesicles, making it a promising candidate as the protein carrier.

中文翻译：

由具有高亲水部分的二元接枝共聚物自组装而成的紧凑囊泡，用于潜在的药物/蛋白质递送

由两亲共聚物自组装的空心囊泡作为药物和蛋白质载体在生物医学领域引起了极大的兴趣。非常需要高效制备具有高体内稳定性的聚合物囊泡。在此，研究了两种具有反向亲水-疏水链段的接枝共聚物（GCP）的新型协同自组装，以实现生物医学应用的形态控制。有趣的是，对于具有相对较高亲水性分数（f_亲水性，~60%），与在其单组分对应物中发现的相反。协同自组装使杂化囊泡具有优异的抗蛋白质吸附、延长血液循环时间以及亲水性药物/蛋白质的低渗漏。此外，蛋白质的生物活性在协同囊泡内得到了很好的保存，使其成为有希望的蛋白质载体候选者。

更新日期：2017-10-10

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