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Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-10-09 , DOI: 10.1002/adhm.201700306 Jalal Mosayebi 1 , Mehdi Kiyasatfar 1 , Sophie Laurent 2
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-10-09 , DOI: 10.1002/adhm.201700306 Jalal Mosayebi 1 , Mehdi Kiyasatfar 1 , Sophie Laurent 2
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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.
中文翻译：
用于治疗学应用的磁性纳米颗粒的合成，功能化和设计
为了将纳米技术转化为医学实践，磁性纳米颗粒（MNP）已作为一种用于多种生物医学应用的非侵入性纳米材料而被提出。尤其是，MNP开辟了一个门，可以同时诊断和快速治疗治疗试剂形式的疾病。这篇综述着重介绍了从合成和功能化步骤到最终设计考虑的MNP制备和利用方面的最新进展，以避开用于治疗和诊断应用的机体免疫系统，并介绍了每个部分中的最新文献。这项研究提供了广泛的合成路线的概念框架，这些合成路线主要分为湿化学，最先进的微流体反应器和生物生成路线，以及最流行的涂料来稳定最终的MNP。此外，通过揭示生物-纳米界面的生物物理相互作用并提供一套有效调节MNP物理化学性质的标准，涵盖了通过克服顺序性生物障碍来延长MNP半衰期的关键方面。此外，详细描述了通过分别利用癌症和新颖的靶向配体的独特特性成功进行细胞内在化的被动和主动靶向的概念。最后，本研究广泛涵盖了磁性药物靶向和热疗作为MNP的治疗应用的最新进展。此外，通过磁共振成像融合实现多模态成像，
更新日期：2017-10-09
中文翻译：
用于治疗学应用的磁性纳米颗粒的合成，功能化和设计
为了将纳米技术转化为医学实践，磁性纳米颗粒（MNP）已作为一种用于多种生物医学应用的非侵入性纳米材料而被提出。尤其是，MNP开辟了一个门，可以同时诊断和快速治疗治疗试剂形式的疾病。这篇综述着重介绍了从合成和功能化步骤到最终设计考虑的MNP制备和利用方面的最新进展，以避开用于治疗和诊断应用的机体免疫系统，并介绍了每个部分中的最新文献。这项研究提供了广泛的合成路线的概念框架，这些合成路线主要分为湿化学，最先进的微流体反应器和生物生成路线，以及最流行的涂料来稳定最终的MNP。此外，通过揭示生物-纳米界面的生物物理相互作用并提供一套有效调节MNP物理化学性质的标准，涵盖了通过克服顺序性生物障碍来延长MNP半衰期的关键方面。此外，详细描述了通过分别利用癌症和新颖的靶向配体的独特特性成功进行细胞内在化的被动和主动靶向的概念。最后，本研究广泛涵盖了磁性药物靶向和热疗作为MNP的治疗应用的最新进展。此外，通过磁共振成像融合实现多模态成像，
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