Cover Feature: Interaction of the N‐Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i‐Motif DNA Sequence (ChemBioChem 20/2017),ChemBioChem

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Cover Feature: Interaction of the N‐Terminal Tandem Domains of hnRNP LL with the BCL2 Promoter i‐Motif DNA Sequence (ChemBioChem 20/2017)
ChemBioChem ( IF 2.6 ) Pub Date : 2017-10-09 , DOI: 10.1002/cbic.201700512
Laurie Lannes ₁ , Phoebe Young ₂ , Christian Richter ₁ , Nina Morgner ₂ , Harald Schwalbe ₁

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The inside cover picture shows the interaction of the transcription factor hnRNP LL with the BCL2 promoter DNA sequence Py39wt. The single‐stranded DNA sequence Py39wt can adopt different conformations in a pH‐dependent manner. Indeed, slightly acidic pH triggers the formation of a tetraplex folding named the i‐motif (left fly), whereas neutral pH leads to a hairpin folding (right fly). The hnRNP LL protein is organised in four RNA recognition motifs (RRMs). In order to bind to Py39wt efficiently, regardless of the DNA conformation, the protein has to engage both of its N‐terminal domains RRM1 and RRM2, like a Venus flytrap simultaneously snaps shut both lobes of its leaves to catch insects. More information can be found in the full paper by H. Schwalbe et al. on page 2033 in Issue 20, 2017 (DOI: 10.1002/cbic.201700390).

中文翻译：

封面文章：hnRNP LL N末端串联结构域与BCL2启动子i-Motif DNA序列的相互作用（ChemBioChem 20/2017）

内封面图片显示了转录因子hnRNP LL与BCL2启动子DNA序列Py39wt的相互作用。单链DNA序列Py39wt可以以pH依赖的方式采用不同的构象。的确，略带酸性的pH会触发名为i-motif的四重折叠的形成（左蝇），而中性pH会导致发夹折叠（右蝇）。hnRNP LL蛋白以四个RNA识别基序（RRM）进行组织。为了有效地结合Py39wt，无论DNA构象如何，该蛋白都必须结合其N末端结构域RRM1和RRM2，就像金星捕蝇器同时捕捉其叶子的两个裂片以捕获昆虫一样。更多信息可以在H. Schwalbe等人的全文中找到。在2017年第20期的第2033页 （DOI：10.1002 / cbic.201700390）。

更新日期：2017-10-09

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