The Oxidation of Hydrophobic Aromatic Substrates by Using a Variant of the P450 Monooxygenase CYP101B1,ChemBioChem

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The Oxidation of Hydrophobic Aromatic Substrates by Using a Variant of the P450 Monooxygenase CYP101B1
ChemBioChem ( IF 2.6 ) Pub Date : 2017-10-09 02:35:41 , DOI: 10.1002/cbic.201700316
Md. Raihan Sarkar ₁ , Joel H. Z. Lee ₁ , Stephen G. Bell ₁

Affiliation

What a bind! The CYP101B1 enzyme from the bacteria N. aromaticivorans has been engineered to better bind and oxidise hydrophobic aromatic substrates. His85 was identified by sequence alignment as a potential active-site residue. The H85F variant improved activity and offered unusual selectivity options.

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