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Apoptosis, Up the Ante.
Cancer Cell ( IF 48.8 ) Pub Date : 2017-Oct-09 , DOI: 10.1016/j.ccell.2017.09.009 Palaniraja Thandapani , Iannis Aifantis
Cancer Cell ( IF 48.8 ) Pub Date : 2017-Oct-09 , DOI: 10.1016/j.ccell.2017.09.009 Palaniraja Thandapani , Iannis Aifantis
The clinical success of the BH3-mimetic venetoclax has generated increasing interest to target BCL2 family proteins in oncology. In this issue of Cancer Cell, Reyna and colleagues demonstrate the potential of a pharmacological activator of the pro-apoptotic protein BAX to suppress acute myeloid leukemia both alone and together with venetoclax.
中文翻译:
凋亡,在前期。
BH3模仿性venetoclax的临床成功引起了越来越多的关注,以靶向BCL2家族蛋白在肿瘤学中。在这一期的《癌细胞》中,Reyna及其同事证明了促凋亡蛋白BAX的药理激活剂有可能单独或与venetoclax一起抑制急性髓细胞性白血病。
更新日期:2017-10-09
中文翻译:
凋亡,在前期。
BH3模仿性venetoclax的临床成功引起了越来越多的关注,以靶向BCL2家族蛋白在肿瘤学中。在这一期的《癌细胞》中,Reyna及其同事证明了促凋亡蛋白BAX的药理激活剂有可能单独或与venetoclax一起抑制急性髓细胞性白血病。