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Exploiting the Hidden Treasure of Detained Introns.
Cancer Cell ( IF 48.8 ) Pub Date : 2017-Oct-09 , DOI: 10.1016/j.ccell.2017.09.005
Xiang-Dong Fu 1
Affiliation  

Many mammalian genes contain poorly spliced introns, resulting in nuclear detention of partially spliced transcripts, which may be exploited to modulate gene expression. In this issue of Cancer Cell, Braun et al. report that the arginine methyltransferase PRMT5 is critical for tumor cell proliferation by regulating numerous detained introns.

中文翻译:

利用被拘留的内含子的隐藏宝藏。

许多哺乳动物基因含有剪接不良的内含子,导致部分剪接的转录本被核滞留,这可用于调节基因表达。在本期《癌细胞》中,布劳恩等人。报道称,精氨酸甲基转移酶 PRMT5 通过调节大量滞留内含子而对肿瘤细胞增殖至关重要。
更新日期:2017-10-09
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