Regioselective C5 alkenylation of 2-acylpyrroles via Pd(ii)-catalyzed C–H bond activation†,Organic Chemistry Frontiers

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Regioselective C5 alkenylation of 2-acylpyrroles via Pd(ii)-catalyzed C–H bond activation†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-10-09 00:00:00 , DOI: 10.1039/c7qo00732a
Jian-Hua Duan _{1,

2,

3,

4} , Rui-Jie Mi _{1,

2,

3,

4} , Jing Sun _{1,

2,

3,

4} , Ming-Dong Zhou _{1,

2,

3,

4}

Affiliation

A Pd(II)-catalyzed regioselective C5 alkenylation of 2-acylpyrroles has been developed employing 3-nitrile benzoyl group (N-(3-NCC₆H₄CO-)) as an efficient N-protecting group. The protocol provided a simple and efficient method to synthesize C5-alkenylated 2-acylpyrrole derivatives. The employed N-protecting group was readily removable in the presence of HCl/EtOH under mild conditions.

中文翻译：

通过Pd（ii）催化的C–H键活化，对2-酰基吡咯的区域选择性C5烯基化作用†

已经开发了使用3-腈苯甲酰基（N-（3-NCC ₆ H ₄ CO-））作为有效的N-保护基的Pd（II）催化的2-酰基吡咯的区域选择性C5烯基化。该协议提供了一种简单有效的方法来合成C5-烯基化的2-酰基吡咯衍生物。所用的N-保护基在温和条件下在HCl / EtOH存在下易于除去。

更新日期：2017-10-09

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