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Sending and Receiving Hedgehog Signals
Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2017-10-06 00:00:00 , DOI: 10.1146/annurev-cellbio-100616-060847
Kostadin Petrov 1 , Bradley M Wierbowski 1 , Adrian Salic 1
Affiliation  

Communication between cells pervades the development and physiology of metazoans. In animals, this process is carried out by a relatively small number of signaling pathways, each consisting of a chain of biochemical events through which extracellular stimuli control the behavior of target cells. One such signaling system is the Hedgehog pathway, which is crucial in embryogenesis and is implicated in many birth defects and cancers. Although Hedgehog pathway components were identified by genetic analysis more than a decade ago, our understanding of the molecular mechanisms of signaling is far from complete. In this review, we focus on the biochemistry and cell biology of the Hedgehog pathway. We examine the unique biosynthesis of the Hedgehog ligand, its specialized release from cells into extracellular space, and the poorly understood mechanisms involved in ligand reception and pathway activation at the surface of target cells. We highlight several critical questions that remain open.

中文翻译:


发送和接收刺猬信号

细胞之间的交流遍及后生动物的发育和生理。在动物中,这个过程是由数量相对较少的信号通路进行的,每个通路都由一系列生化事件组成,细胞外刺激通过这些事件控制靶细胞的行为。一种这样的信号系统是 Hedgehog 通路,它在胚胎发生中至关重要,并且与许多先天缺陷和癌症有关。尽管十多年前通过遗传分析鉴定了 Hedgehog 通路成分,但我们对信号分子机制的理解还远未完成。在这篇综述中,我们关注 Hedgehog 通路的生物化学和细胞生物学。我们研究了 Hedgehog 配体的独特生物合成,它从细胞专门释放到细胞外空间,以及对靶细胞表面配体接收和通路激活的机制知之甚少。我们强调了几个仍然悬而未决的关键问题。

更新日期:2017-10-06
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