Transcutaneous immunization (TCI) is a promising alternative to vaccine delivery via the subcutaneous and intramuscular routes because of the unique immunological characteristics of the skin. However, the stratum corneum (SC) prevents entry of most therapeutic compounds into the body. Several physical devices have been developed to overcome the SC barrier, but still damage the skin. However, by targeting antigens to the abundant perifollicular antigen-presenting cells (APCs), the transfollicular route might be a promising approach for TCI without compromising the skin barrier.

中文翻译：

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克服或避开角质层屏障，进行有效的经皮免疫

由于皮肤独特的免疫学特性，经皮免疫（TCI）是通过皮下和肌内途径疫苗接种的有前途的替代方法。但是，角质层（SC）会阻止大多数治疗性化合物进入体内。已经开发出了几种物理设备来克服SC障碍，但仍然会损害皮肤。但是，通过将抗原靶向丰富的毛囊周围抗原呈递细胞（APC），跨卵泡途径对于TCI可能是一种有前途的方法，而不会损害皮肤屏障。