Thorough molecular characterization of reference viruses supports the detection of emerging human pathogens as well as studies of evolutionary relationships. However, full characterization of the tripartite RNA genomes of many viruses of the clinically important family Peribunyaviridae remains incomplete, making it difficult to identify emerging strains. Here, we report the full genome sequences of nine viruses belonging to the California serogroup and describe multi-segment analyses of these and previously published California serogroup strain data to determine the role of segment reassortment in the evolution of this serogroup. Phylogenetic trees from the small, medium, and large segments suggest long term, independent evolution of the majority of strains. However, trees from each segment were not entirely congruent and evidence of reassortment among some strains is presented. Of unique interest, the L segment phylogeny reveals divergent branching patterns for encephalitic versus non-encephalitic viruses in both major clades of the California serogroup.

参考病毒的全面分子表征支持检测新兴的人类病原体以及研究进化关系。然而，临床上重要的Peribunyaviridae家族的许多病毒的三方RNA基因组的完整特征仍然不完整，因此很难识别新出现的菌株。在这里，我们报告了属于加利福尼亚血清群的九种病毒的完整基因组序列，并描述了这些病毒的多片段分析以及先前发布的加利福尼亚血清群毒株数据，以确定区段重组在该血清群进化中的作用。来自小型，中型和大型区段的系统发育树表明大多数菌株的长期，独立进化。然而，来自每个部分的树木并不完全一致，并且提供了一些菌株之间重配的证据。引起人们极大兴趣的是，L段系统发育揭示了在加州血清群的两个主要进化枝中脑炎病毒和非脑炎病毒的不同分支模式。