Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a lifetime prevalence of nearly 8% in the general population. While the underlying molecular and cellular mechanisms of PTSD remain unknown, recent studies indicate that PTSD is associated with aberrant gene expression in brain as well as peripheral blood cells. The advent of next-generation sequencing technologies will allow us to elucidate the gene expression changes occurring in both brain and blood of patients with PTSD. RNA sequencing allows for analysis of the amount of transcript being made as well as alternative splicing, novel transcript identification, microRNA, and noncoding RNA quantification. Here we provide an overview of the different types of transcriptomic technologies as well as the gene expression studies performed in human peripheral blood and animal models of PTSD, and review the human PTSD postmortem brain gene profiling studies performed to date.

中文翻译：

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创伤后应激障碍的转录组改变

创伤后应激障碍 (PTSD) 是一种使人衰弱的精神疾病，在普通人群中的终生患病率接近 8%。虽然 PTSD 的潜在分子和细胞机制仍然未知，但最近的研究表明，PTSD 与大脑和外周血细胞中的异常基因表达有关。新一代测序技术的出现将使我们能够阐明 PTSD 患者大脑和血液中发生的基因表达变化。RNA 测序允许分析正在制作的转录本的数量以及选择性剪接、新型转录本鉴定、microRNA 和非编码 RNA 定量。