Herein we disclose the report on the synthesis of α-trifluoromethylseleno-substituted ketone derivatives via copper-mediated trifluoromethylselenolation of α-bromoketones with [(bpy)Cu(SeCF₃)]₂ 1. A broad range of substituted 2-bromoacetophenone substrates were found to react smoothly with 1 in the presence of 3 equiv of K₃PO₄ to afford the corresponding α-trifluoromethylseleno-substituted ketones in good yields. A wide range of functional groups were well tolerated and the reaction conditions are amenable to scale up.

中文翻译：

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α-Trifluoromethylseleno取代酮合成经由α-溴酮的铜介导的trifluoromethylselenolation

在这里，我们公开了通过[（bpy）Cu（SeCF ₃）] ₂ 1通过铜介导的α-溴代酮的三氟甲基硒化反应合成α-三氟甲基硒代酮衍生物的报告。发现了广泛的取代2-溴苯乙酮底物在3当量的K ₃ PO ₄的存在下，与1平滑反应，以高收率得到相应的α-三氟甲基硒代取代的酮。各种各样的官能团被很好地耐受，并且反应条件适合扩大规模。