A new reaction route for the synthesis of 2-methyl-5-ethylpyridine,Reaction Chemistry & Engineering

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A new reaction route for the synthesis of 2-methyl-5-ethylpyridine
Reaction Chemistry & Engineering ( IF 3.4 ) Pub Date : 2017-08-29 00:00:00 , DOI: 10.1039/c7re00100b
Emanuele Moioli _{1,

2,

3,

4,

5} , Leo Schmid _{5,

6,

7} , Peter Wasserscheid _{1,

2,

3,

4} , Hannsjörg Freund _{1,

2,

3,

4}

Affiliation

In this work, a novel synthesis route to produce 2-methyl-5-ethylpyridine (MEP) from the cyclic acetaldehyde ammonia trimer (AAT) is explored. The reaction was studied in a semi-batch reactor in the presence of different promoters to adjust the pH of the reaction solution. Among various ammonium salts tested as promoters, ammonium acetate was identified as the most suitable promoter for the reaction. By using a Design of Experiments (DoE) approach, the temperature and concentration of reactants and the promoter were identified as the most important/decisive parameters influencing the course of the reaction. Additional mechanistic investigations were carried out to assess the effect of these parameters in detail and to clarify the by-product formation via oligomer formation.

中文翻译：

合成2-甲基-5-乙基吡啶的新反应路线

在这项工作中，探索了一种从环状乙醛氨三聚体（AAT）生产2-甲基-5-乙基吡啶（MEP）的新颖合成途径。在不同的促进剂的存在下，在半间歇反应器中研究反应，以调节反应溶液的pH。在作为促进剂测试的各种铵盐中，乙酸铵被确定为最适合该反应的促进剂。通过使用实验设计（DoE）方法，将反应物和促进剂的温度和浓度确定为影响反应过程的最重要/决定性参数。进行了额外的机械研究，以详细评估这些参数的作用并阐明通过低聚物形成的副产物的形成。

更新日期：2017-10-03

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