Abstract Polymer based dosages form the mainstay of drug delivery systems either as simple matrix carrier materials or active release behavior modulating agents. In addition, several techniques have been developed further to deliver novel polymeric structures. One such method is electrospinning (ES); a maturing process which is operational at the ambient environment and enables drug loading (in molecularly dispersed form) directly into a fibrous polymer matrix system. Since there is an impending need to address healthcare challenges arising from an increase in the aging population (requiring enhanced treatments), the ES method was used to develop fibrous polymer composite-indomethacin (INDO) films for potential use in the buccal region. Films were assessed for their inter-facial behavior at bio-interfaces (in-vitro and ex-vivo). Polymeric excipients possessing an established profile for commercial dosage form development were selected. Fibrous films (all fibre components

中文翻译：

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纤维聚合物口腔膜配方、工程和生物界面评估

摘要 基于聚合物的剂型作为简单的基质载体材料或活性释放行为调节剂形成了药物递送系统的支柱。此外，还进一步开发了几种技术来提供新型聚合物结构。一种这样的方法是静电纺丝（ES）；一种成熟过程，可在周围环境中运行，并使药物（以分子分散形式）直接加载到纤维聚合物基质系统中。由于迫切需要解决因人口老龄化（需要加强治疗）而带来的医疗保健挑战，因此使用 ES 方法开发纤维聚合物复合吲哚美辛 (INDO) 薄膜，以用于口腔区域的潜在用途。评估薄膜在生物界面（体外和离体）的界面行为。选择了具有确定的商业剂型开发特征的聚合物赋形剂。纤维薄膜（所有纤维成分