Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms,Chemical Research in Toxicology

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Potential of Phenylbutyrate as Adjuvant Chemotherapy: An Overview of Cellular and Molecular Anticancer Mechanisms
Chemical Research in Toxicology ( IF 3.7 ) Pub Date : 2017-10-03 00:00:00 , DOI: 10.1021/acs.chemrestox.7b00149
Maha S. Al-Keilani ₁ , Nour A. Al-Sawalha ₁

Affiliation

Despite the advancement in cancer therapy, a high number of patients fail treatment because of drug resistance. Several preclinical in vitro data suggest that phenylbutyrate has antiproliferative, antiangiogenic, antimetastatic, immunomodulatory, and differentiating properties. Moreover, phenylbutyrate administration in vivo provided an oncoprotective effect. However, the results of clinical trials indicate that the antineoplastic potential of phenylbutyrate is hindered by its pharmacokinetic and pharmacodynamic properties. Thus, understanding the exact mechanisms of the anticancer effect of phenylbutyrate could assist in the selection of patients who will best benefit from this drug. The present review discusses the proposed mechanisms of antineoplastic effect of phenylbutyrate and the preclinical and clinical evidence suggesting its potential role as anticancer in different types of cancer.

中文翻译：

苯丁酸作为辅助化疗的潜力：细胞和分子抗癌机制的概述。

尽管癌症治疗取得了进步，但仍有许多患者由于耐药性而使治疗失败。临床前的一些体外数据表明，丁酸苯酯具有抗增殖，抗血管生成，抗转移，免疫调节和分化的特性。此外，体内丁酸苯酯的给药提供了抑癌作用。但是，临床试验结果表明，苯基丁酸酯的抗肿瘤潜力受到其药代动力学和药效动力学特性的阻碍。因此，了解苯基丁酸抗癌作用的确切机制可以帮助选择最能从该药物中受益的患者。本文对苯丁酸苯酯的抗肿瘤作用机制进行了讨论，并提出了临床前和临床证据，表明其在不同类型的癌症中作为抗癌药的潜在作用。

更新日期：2017-10-03

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