6″-¹⁸F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize most bacterial infections, much like ¹⁸F-FDG has been used to image and localize most cancers. However, unlike ¹⁸F-FDG, 6″-¹⁸F-fluoromaltotriose is not taken up by inflammatory lesions and appears to be specific to bacterial infections by targeting the maltodextrin transporter that is expressed in gram-positive and gram-negative strains of bacteria. Methods: 6″-¹⁸F-fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically relevant bacterial strains in cultures and in living mice. Results: 6″-¹⁸F-fluoromaltotriose was taken up in both gram-positive and gram-negative bacterial strains. 6″-¹⁸F-fluoromaltotriose was also able to detect Pseudomonas aeruginosa in a clinically relevant mouse model of wound infection. The utility of 6″-¹⁸F-fluoromaltotriose to help monitor antibiotic therapies was also evaluated in rats. Conclusion: 6″-¹⁸F-fluoromaltotriose is a promising new tracer that has significant diagnostic utility, with the potential to change the clinical management of patients with infectious diseases of bacterial origin.

6″ ^-18 F-氟麦芽三糖是一种PET示踪剂，可潜在地用于成像和定位大多数细菌感染，就像¹⁸ F-FDG已用于成像和定位大多数癌症。然而，与¹⁸ F-FDG，6“ - ¹⁸ F-fluoromaltotriose不采取了由炎性病变和出现通过靶向在细菌的革兰氏阳性和革兰氏阴性菌株中表达的麦芽糖糊精转运到特定于细菌感染。方法：合成了具有高放射化学纯度的6” ^-18 F-氟代麦芽三糖，并在培养物中和活体小鼠中的几种临床相关细菌菌株中进行了评估。结果： 6″ ^-18F-氟麦芽三糖被革兰氏阳性和革兰氏阴性细菌吸收。6” ^-18 F-氟代麦芽三糖还能够在临床相关的伤口感染小鼠模型中检测到铜绿假单胞菌。在大鼠中还评估了6''- ¹⁸ F-氟代麦芽三糖有助于监测抗生素治疗的效用。结论： 6″ ^-18 F-氟代麦芽三糖是一种很有前途的新型示踪剂，具有重要的诊断用途，并有可能改变细菌源性传染病患者的临床管理。