Great progress has been made in in vivo imaging for cancer metastasis. Eisenblaetter et al. developed an innovative S100A8/A9-specific single photon emission computed tomography (SPECT) probe for imaging and succeeded in detecting the metastatic organ favored by the cancer before the cancer arrival. By utilizing this advanced method, researchers have also found that cancer-derived monocytes are the main source of the abundant production of S100A8/A9 in the pre-metastatic area. The CCL2-CCR2 axis is associated with S100A8/A9 production. Clinical establishment of this technique is expected to enable accurate prediction and monitoring of cancer metastasis during therapy.

中文翻译：

---

S100-SPECT发现转移前的利基形成和器官特异性癌症转移后的细胞和分子事件

在体内成像中用于癌症转移的研究取得了巨大进展。Eisenblaetter等。开发了一种创新的S100A8 / A9特异性单光子发射计算机断层扫描（SPECT）探针进行成像，并成功地在癌症到来之前检测出癌症偏爱的转移器官。通过利用这种先进的方法，研究人员还发现，癌源性单核细胞是转移前区域S100A8 / A9大量产生的主要来源。CCL2-CCR2轴与S100A8 / A9的生产相关。期望该技术的临床建立能够在治疗期间准确预测和监测癌症转移。