Dynamic Docking and Undocking Processes Addressing Selectively the Outside and Inside of Polymersomes,Macromolecular Rapid Communications

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Dynamic Docking and Undocking Processes Addressing Selectively the Outside and Inside of Polymersomes
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2017-09-27 , DOI: 10.1002/marc.201700486
Banu Iyisan ₁ , Anna Charlott Siedel ₁ , Hannes Gumz ₁ , Mohamed Yassin ₂ , Jörg Kluge ₁ , Jens Gaitzsch ₃ , Petr Formanek ₁ , Silvia Moreno ₁ , Brigitte Voit ₁ , Dietmar Appelhans ₁

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Increasing complexity and diversity of polymersomes and their compartments is a key issue for mimicking cellular functions and protocells. Thus, new challenges arise in terms of achieving tunable membrane permeability and combining it with control over the membrane diffusion process, and thus enabling a localized and dynamic control of functionality and docking possibilities within or on the surface of polymeric compartments. This study reports the concept of polymersomes with pH‐tunable membrane permeability for controlling sequential docking and undocking processes of small molecules and nanometer‐sized protein mimics selectively on the inside and outside of the polymersome membrane as a further step toward the design of intelligent multifunctional compartments for use in synthetic biology and as protocells. Host–guest interactions between adamantane and β‐cyclodextrin as well as noncovalent interactions between poly(ethylene glycol) tails and β‐cyclodextrin are used to achieve selective and dynamic functionalization of the inner and outer spheres of the polymersome membrane.

中文翻译：

动态对接和卸接过程选择性地解决了聚合物小体的内部和外部

聚合体及其区室的复杂性和多样性不断增加，是模仿细胞功能和原始细胞的关键问题。因此，在实现可调节的膜渗透性并将其与对膜扩散过程的控制相结合方面出现了新的挑战，从而实现了对聚合物隔室内部或表面上的功能性和对接可能性的局部和动态控制。这项研究报告了具有可调节pH值的膜通透性的聚合物小体的概念，可用于控制小分子和纳米级蛋白质模拟物在聚合物小体膜的内部和外部选择性的顺序对接和解扣过程，这是朝着设计智能多功能隔室迈出的又一步用于合成生物学和原生细胞。

更新日期：2017-09-27

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