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Strategies for Optimizing the Soft Tissue Seal around Osseointegrated Implants
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-09-27 , DOI: 10.1002/adhm.201700549 Mohamed-Nur Abdallah 1, 2 , Zahi Badran 1, 3 , Ovidiu Ciobanu 1 , Nader Hamdan 4 , Faleh Tamimi 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-09-27 , DOI: 10.1002/adhm.201700549 Mohamed-Nur Abdallah 1, 2 , Zahi Badran 1, 3 , Ovidiu Ciobanu 1 , Nader Hamdan 4 , Faleh Tamimi 1
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Percutaneous and permucosal devices such as catheters, infusion pumps, orthopedic, and dental implants are commonly used in medical treatments. However, these useful devices breach the soft tissue barrier that protects the body from the outer environment, and thus increase bacterial infections resulting in morbidity and mortality. Such associated infections can be prevented if these devices are effectively integrated with the surrounding soft tissue, and thus creating a strong seal from the surrounding environment. However, so far, there are no percutaneous/permucosal medical devices able to prevent infection by achieving strong integration at the soft tissue–device interface. This review gives an insight into the current status of research into soft tissue–implant interface and the challenges associated with these interfaces. Biological soft/hard tissue interfaces may provide insights toward engineering better soft tissue interfaces around percutaneous devices. In this review, focus is put on the history and current findings as well as recent progress of the strategies aiming to develop a strong soft tissue seal around osseointegrated implants, such as orthopedic and dental implants.
中文翻译：
优化骨整合植入物周围软组织密封的策略
经皮和粘膜装置，例如导管，输液泵，整形外科和牙科植入物，通常用于医学治疗。然而，这些有用的装置突破了软组织屏障，保护了身体免受外部环境的侵害，从而增加了细菌感染，导致发病率和死亡率。如果这些设备与周围的软组织有效整合，从而与周围环境形成牢固的密封，则可以防止此类相关感染。但是，到目前为止，还没有经皮/粘膜的医疗器械能够通过在软组织-器械界面实现牢固的整合来预防感染。这篇综述提供了对软组织-植入物界面的研究现状以及与这些界面相关的挑战的见解。生物软/硬组织界面可能为设计经皮设备周围更好的软组织界面提供了见识。在这篇综述中，重点是策略的历史和当前发现以及策略的最新进展，这些策略旨在在骨集成植入物（例如整形外科和牙科植入物）周围形成牢固的软组织密封。
更新日期：2017-09-27
中文翻译：
优化骨整合植入物周围软组织密封的策略
经皮和粘膜装置，例如导管，输液泵，整形外科和牙科植入物，通常用于医学治疗。然而，这些有用的装置突破了软组织屏障，保护了身体免受外部环境的侵害，从而增加了细菌感染，导致发病率和死亡率。如果这些设备与周围的软组织有效整合，从而与周围环境形成牢固的密封，则可以防止此类相关感染。但是，到目前为止，还没有经皮/粘膜的医疗器械能够通过在软组织-器械界面实现牢固的整合来预防感染。这篇综述提供了对软组织-植入物界面的研究现状以及与这些界面相关的挑战的见解。生物软/硬组织界面可能为设计经皮设备周围更好的软组织界面提供了见识。在这篇综述中，重点是策略的历史和当前发现以及策略的最新进展，这些策略旨在在骨集成植入物（例如整形外科和牙科植入物）周围形成牢固的软组织密封。
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