The strong dependence of retroviruses, such as human immunodeficiency virus type 1 (HIV-1), on host cell factors is no more apparent than when the endosomal sorting complex required for transport (ESCRT) machinery is purposely disengaged. The resulting potent inhibition of retrovirus release underscores the importance of understanding fundamental structure-function relationships at the ESCRT-HIV-1 interface. Recent studies utilizing advanced imaging technologies have helped clarify these relationships, overcoming hurdles to provide a range of potential models for ESCRT-mediated virus abscission. Here, we discuss these models in the context of prior work detailing ESCRT machinery and the HIV-1 release process. To provide a template for further refinement, we propose a new working model for ESCRT-mediated HIV-1 release that reconciles disparate and seemingly conflicting studies.

中文翻译：

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ESCRT介导的人类免疫缺陷病毒1型脱落的共识性观点。

逆转录病毒（例如1型人类免疫缺陷病毒（HIV-1））对宿主细胞因子的强烈依赖性比故意分离运输所需的内体分选复合物（ESCRT）机器时更不明显。产生的对逆转录病毒释放的有效抑制作用强调了理解ESCRT-HIV-1界面的基本结构-功能关系的重要性。最近利用先进的成像技术进行的研究已经帮助阐明了这些关系，克服了障碍，为ESCRT介导的病毒脱落提供了一系列潜在的模型。在这里，我们将在先前的工作中详细讨论ESCRT机制和HIV-1释放过程，讨论这些模型。为了提供进一步完善的模板，