Over the past few years our understanding of estrogen signaling in the brain has expanded rapidly. Estrogens are synthesized in the periphery and in the brain, acting on multiple receptors to regulate gene transcription, neural function, and behavior. Various estrogen-sensitive signaling pathways often operate in concert within the same cell, increasing the complexity of the system. In females, estrogen concentrations fluctuate over the estrous/menstrual cycle, dynamically modulating estrogen receptor (ER) expression, activity, and trafficking. These dynamic changes influence multiple behaviors but are particularly important for reproduction. Using the female rodent model, we review our current understanding of estradiol signaling in the regulation of sexual receptivity.

中文翻译：

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脑中雌二醇膜引发的信号传导介导生殖

在过去的几年里，我们对大脑中雌激素信号的理解迅速扩大。雌激素在外周和大脑中合成，作用于多种受体以调节基因转录、神经功能和行为。各种雌激素敏感信号通路通常在同一细胞内协同运作，增加了系统的复杂性。在女性中，雌激素浓度在动情/月经周期中波动，动态调节雌激素受体 (ER) 的表达、活性和运输。这些动态变化会影响多种行为，但对繁殖尤其重要。使用雌性啮齿动物模型，我们回顾了我们目前对调节性接受能力的雌二醇信号传导的理解。