The tremendous increase in allergy in the African continent cannot simply be explained by the change in public hygiene. There are many “prehygiene” communities with sewage-contaminated water supplies, helminth infestations, bare footedness, and poor housing, and still there is a high prevalence of allergic disease. Africans can be exposed to many risk factors facilitating severe asthma and wheezing, including airborne viruses, smoke, indoor dampness, cockroaches, and poor access to health care. Although the reporting on food allergy is inadequate to perform systematic reviews or meta-analyses, the available data suggest that food allergy is underdiagnosed. The rate of new HIV infections in high-prevalence settings in Africa remains unacceptably high. Although the annual number of new HIV infections in Sub-Saharan Africa has decreased lately, new HIV infections in the Middle East and North Africa region have increased; however, the current prevalence of 0.1% is still among the lowest globally. Africa is densely populated, and consanguineous mating is high in some areas of North and Sub-Saharan Africa. This allows for emergence of many autosomal recessive primary immunodeficiency diseases. There is urgent need for the establishment of primary immunodeficiency disease registries, stem cell transplantation facilities, and neonatal screening programs. To address these expanding problems and perform local cutting-edge research, Africans need to be empowered by motivated governments, dedicated funds, and compassionate scientific partnership.

非洲大陆过敏症的急剧增加不能简单地用公共卫生的变化来解释。有许多“卫生前”社区，这些社区的供水受到污水的污染，蠕虫的侵扰，光秃秃的脚步和居住条件差，而且过敏性疾病的患病率仍然很高。非洲人可能会面临许多导致严重哮喘和喘息的危险因素，包括空气传播的病毒，烟雾，室内潮湿，蟑螂和难以获得医疗保健。尽管有关食物过敏的报道不足以进行系统的综述或荟萃分析，但现有数据表明食物过敏的诊断不足。在非洲高流行地区，新的艾滋病毒感染率仍然很高，令人无法接受。尽管最近在撒哈拉以南非洲地区，每年新增的艾滋病毒感染人数有所减少，中东和北非地区新的艾滋病毒感染增加了；但是，目前的流行率为0.1％，仍然是全球最低的流行率之一。非洲人口稠密，北非和撒哈拉以南非洲的某些地区近亲交配很高。这允许出现许多常染色体隐性遗传性原发性免疫缺陷疾病。迫切需要建立主要的免疫缺陷疾病注册表，干细胞移植设施和新生儿筛查计划。为了解决这些不断扩大的问题并进行本地前沿研究，非洲人需要有积极进取的政府，专门的基金和富有同情心的科学伙伴关系来赋权。非洲人口稠密，北非和撒哈拉以南非洲的某些地区近亲交配很高。这允许出现许多常染色体隐性遗传性原发性免疫缺陷疾病。迫切需要建立主要的免疫缺陷疾病注册表，干细胞移植设施和新生儿筛查计划。为了解决这些不断扩大的问题并进行本地前沿研究，非洲人需要有积极进取的政府，专门的基金和富有同情心的科学伙伴关系来赋权。非洲人口稠密，北非和撒哈拉以南非洲的某些地区近亲交配很高。这允许出现许多常染色体隐性遗传性原发性免疫缺陷疾病。迫切需要建立主要的免疫缺陷疾病注册表，干细胞移植设施和新生儿筛查计划。为了解决这些不断扩大的问题并进行本地前沿研究，非洲人需要有积极进取的政府，专门的基金和富有同情心的科学伙伴关系来赋权。干细胞移植设施和新生儿筛查程序。为了解决这些不断扩大的问题并进行本地前沿研究，非洲人需要有积极进取的政府，专门的基金和富有同情心的科学伙伴关系来赋权。干细胞移植设施和新生儿筛查程序。为了解决这些不断扩大的问题并进行本地前沿研究，非洲人需要有积极进取的政府，专门的基金和富有同情心的科学伙伴关系来赋权。