Since the initial discovery that the interparticle nanogaps in nanoparticle aggregates was the surface-enhanced Raman scattering(SERS) hotspots that facilitated the enormous enhancements in SERS, the controllable assembly of plasmonic nanoparticles into superstructures is recognized as the most effective strategy for fabricating SERS substrate. The homogenous distribution abundant SERS hotspots inside the self-assembly reproducibly amplify the SERS signal. This ultimately makes SERS an ultrasensitive analytical method with the potential to elicit fundamental chemistry, biology, and physics breakthroughs.This review focuses on recent developments in self-assemble of plasmonic NPs for SERS applications, including:

1)

Template-guided self-assemble of plasmonic NPs

2)

Templateless self-assemble of plasmonic NPs

3)

Taking full advantage of the assembly process: integration of target analyte recognition and capture capacity into the assembly

4)

Assembly makes perfect: new opportunities created by large self-assembling SERS substrates.

5)

Future directions and possible applications of self-assembled SERS substrates.

1)

Template-guided self-assemble of plasmonic NPs

2)

Templateless self-assemble of plasmonic NPs

3)

Taking full advantage of the assembly process: integration of target analyte recognition and capture capacity into the assembly

4)

Assembly makes perfect: new opportunities created by large self-assembling SERS substrates.

5)

Future directions and possible applications of self-assembled SERS substrates.

中文翻译：

---

将等离子纳米结构自组装成超晶格，用于表面增强拉曼散射应用

由于最初发现纳米粒子聚集体中的粒子间纳米间隙是促进SERS极大增强的表面增强拉曼散射（SERS）热点，因此将等离子体纳米粒子可控地组装成超结构被公认为是制造SERS基板的最有效策略。自组装内部均匀分布的丰富SERS热点可再现地放大SERS信号。这最终使SERS成为一种超灵敏的分析方法，有可能在基础化学，生物学和物理学方面取得突破。

1）

模板引导的等离子NP的自组装

2）

等离子NP的无模板自组装

3）

充分利用组装过程的优势：将目标分析物的识别和捕获能力整合到组装中

4）

组装非常完美：大型的自组装SERS基板带来了新的机遇。

5）

自组装SERS基板的未来方向和可能的应用。

1）

模板引导的等离子NP的自组装

2）

等离子NP的无模板自组装

3）

充分利用组装过程的优势：将目标分析物的识别和捕获能力整合到组装中

4）

组装非常完美：大型的自组装SERS基板带来了新的机遇。

5）

自组装SERS基板的未来方向和可能的应用。