Low genetic diversity of Epizootic haematopoietic necrosis virus (EHNV) was determined for the complete genome of 16 isolates spanning the natural range of hosts, geography and time since the first outbreaks of disease. Genomes ranged from 125,591–127,487 nucleotides with 97.47% pairwise identity and 106–109 genes. All isolates shared 101 core genes with 121 potential genes predicted within the pan-genome of this collection. There was high conservation within 90,181 nucleotides of the core genes with isolates separated by average genetic distance of 3.43 × 10⁻⁴ substitutions per site. Evolutionary analysis of the core genome strongly supported historical epidemiological evidence of iatrogenic spread of EHNV to naïve hosts and establishment of endemic status in discrete ecological niches. There was no evidence of structural genome reorganization, however, the complement of non-core genes and variation in repeat elements enabled fine scale molecular epidemiological investigation of this unpredictable pathogen of fish.

确定了自疾病首次爆发以来跨越宿主自然范围，地理和时间的16个分离株的完整基因组的流行性造血坏死病毒（EHNV）的低遗传多样性。基因组范围为125,591-127,487个核苷酸，成对一致性为97.47％，具有106-109个基因。所有分离物共有101个核心基因，并在该集合的全基因组中预测了121个潜在基因。核心基因的90,181个核苷酸内具有高度保守性，分离株之间的平均遗传距离为3.43×10 ^-4每个网站的替换次数。核心基因组的进化分析强有力地支持了EHNV医源性传播至幼稚宿主并在离散的生态位中建立流行状态的历史流行病学证据。没有证据表明结构基因组重组，但是，非核心基因的互补和重复元件的变异使得对这种不可预测的鱼病原体进行了大规模的分子流行病学研究。