The TEAD transcription factor family is best known for transcriptional output of the Hippo signaling pathway and has been implicated in processes such as development, cell growth and proliferation, tissue homeostasis, and regeneration. Our understanding of the functional importance of TEADs has increased dramatically since its initial discovery three decades ago. The majority of our knowledge of TEADs is in the context of Hippo signaling as nuclear DNA-binding proteins passively activated by Yes-associated protein (YAP) and transcriptional activator with PDZ-binding domain (TAZ), transcription coactivators downstream of the Hippo pathway. However, recent studies suggest that TEAD itself is actively regulated. Here, we highlight evidence demonstrating Hippo-independent regulation of TEADs and the potential impacts these studies may have on new cancer therapeutics.

TEAD转录因子家族以河马信号转导途径的转录输出而闻名，并与诸如发育，细胞生长和增殖，组织稳态和再生等过程有关。自从三十年前首次发现TEAD以来，我们对TEAD的功能重要性的了解已大大增加。我们对TEADs的大多数了解是在Hippo信号传导的背景下进行的，它是由Yes相关蛋白（YAP）和具有PDZ结合域（TAZ）的转录激活因子（Hippo途径下游的转录共激活因子）被动激活的核DNA结合蛋白。但是，最近的研究表明，TEAD本身是受到积极调节的。这里，