While clues have existed that endosomal trafficking is associated with Alzheimer's disease (AD), whether it plays a central role in the disease and if so how has remained unknown. Here we rely on recent genetic and cellular findings to construct a model proposing that traffic jams in the early endosome can act as an upstream pathogenic hub in AD. We also rely on an independent series of findings to suggest how the traffic jams can act as a unified mediator of downstream pathophysiology. The model predicts, therefore, that interventions designed to unjam the endosome carry high therapeutic promise.

中文翻译：

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内体交通堵塞代表阿尔茨海默病的致病中心和治疗靶点

虽然存在内体贩运与阿尔茨海默病 (AD) 相关的线索，但它是否在该疾病中发挥核心作用以及如果是这样仍然未知。在这里，我们依靠最近的遗传和细胞发现来构建一个模型，该模型提出早期内体中的交通拥堵可以作为 AD 的上游致病中心。我们还依靠一系列独立的发现来建议交通拥堵如何作为下游病理生理学的统一中介。因此，该模型预测旨在疏通内体的干预措施具有很高的治疗前景。