Phosphine catalyzed δ-carbon addition and isomerization of alkynones to ketimines: the preparation of 1,3-diene substituted dihydroquinazolinones and 3-aminooxindoles†,Organic Chemistry Frontiers

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Phosphine catalyzed δ-carbon addition and isomerization of alkynones to ketimines: the preparation of 1,3-diene substituted dihydroquinazolinones and 3-aminooxindoles†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-09-28 00:00:00 , DOI: 10.1039/c7qo00772h
Yao-Liang Sun _{1,

2,

3,

4,

5} , Yin Wei _{6,

7,

8,

9,

10} , Min Shi _{1,

2,

3,

4,

5}

Affiliation

In this paper, we disclosed that alkynones could be activated as nucleophilic synthons of dienes to smoothly react with several ketimines upon phosphine catalysis, providing three kinds of α-amino diene derivatives in moderate to excellent yields. A plausible mechanism has been proposed on the basis of control experiments. Transformations of 3,5-dien-2-one derivatives were also performed to provide diverse polyene products.

中文翻译：

膦催化炔烃的δ-碳加成和异构化为酮亚胺：1,3-二烯取代的二氢喹唑啉酮和3-氨基氧吲哚的制备†

在本文中，我们公开了炔烃可被活化为二烯的亲核合成子，从而在膦催化下与几种酮亚胺平稳反应，从而以中等至极好的收率提供了三种α-氨基二烯衍生物。在控制实验的基础上，提出了一种合理的机制。还进行了3，5-二烯-2-酮衍生物的转化以提供多种多烯产物。

更新日期：2017-09-28

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