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Calcium-mediated one-pot preparation of isoxazoles with deuterium incorporation†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-09-28 00:00:00 , DOI: 10.1039/c7qo00705a Maria S. Ledovskaya 1, 2, 3 , Konstantin S. Rodygin 1, 2, 3 , Valentine P. Ananikov 1, 2, 3, 4, 5
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2017-09-28 00:00:00 , DOI: 10.1039/c7qo00705a Maria S. Ledovskaya 1, 2, 3 , Konstantin S. Rodygin 1, 2, 3 , Valentine P. Ananikov 1, 2, 3, 4, 5
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In this work, a novel synthetic methodology for the one-pot preparation of isoxazoles directly from the reaction of calcium carbide with aldoximes is reported. Calcium carbide acts as a safe and inexpensive acetylene source and, in addition, as a source of the Ca(OH)2 base to enable the generation of nitrile oxide. Various 3-substituted isoxazoles were synthesized from the corresponding aldoximes in good yields (up to 95%) and a series of new deuterated 4,5-dideuteroisoxazoles were prepared.
中文翻译：
掺入氘的钙介导的一锅异恶唑的制备†
在这项工作中，报道了一种直接从电石与醛肟的反应中一锅制备异恶唑的新颖合成方法。碳化钙是一种安全且廉价的乙炔源，此外，它还是Ca（OH）2碱的来源，可生成一氧化二氮。从相应的醛肟以高收率（高达95％）合成了各种3-取代的异恶唑，并制备了一系列新的氘代4,5-二氘异恶唑。
更新日期：2017-09-28
中文翻译：
掺入氘的钙介导的一锅异恶唑的制备†
在这项工作中，报道了一种直接从电石与醛肟的反应中一锅制备异恶唑的新颖合成方法。碳化钙是一种安全且廉价的乙炔源，此外，它还是Ca（OH）2碱的来源，可生成一氧化二氮。从相应的醛肟以高收率（高达95％）合成了各种3-取代的异恶唑，并制备了一系列新的氘代4,5-二氘异恶唑。
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