Renal physiology: Prostaglandins in thiazide-induced hyponatraemia: do they hold water?

Nature Reviews Nephrology, Published online: 25 September 2017; doi:10.1038/nrneph.2017.133

Thiazide diuretics lower blood pressure and cardiovascular risk but can cause severe hyponatraemia. Researchers now demonstrate that thiazide-induced hyponatraemia is associated with a genetic variant in a distal nephron prostaglandin transporter. They propose that reduced prostaglandin reabsorption through this transporter facilitates activation of the prostaglandin EP4 receptor to increase water reabsorption.

中文翻译：

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肾脏生理学：前列腺素在噻嗪类低钠血症中的作用：它们是否持水？

肾脏生理学：前列腺素在噻嗪类低钠血症中的作用：它们是否持水？

Nature Reviews Nephrology，在线发布：2017年9月25日；doi：10.1038 / nrneph.2017.133

噻嗪类利尿剂可降低血压和心血管风险，但可引起严重的低钠血症。现在，研究人员证明了噻嗪类引起的低钠血症与远端肾单位前列腺素转运蛋白的遗传变异有关。他们提出，通过该转运蛋白减少的前列腺素重吸收促进了前列腺素EP4受体的活化以增加水的重吸收。