Rapid Visible Light-Mediated Controlled Aqueous Polymerization with In Situ Monitoring,ACS Macro Letters

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Rapid Visible Light-Mediated Controlled Aqueous Polymerization with In Situ Monitoring
ACS Macro Letters ( IF 5.1 ) Pub Date : 2017-09-22 00:00:00 , DOI: 10.1021/acsmacrolett.7b00587
Jia Niu ₁ , Zachariah A Page , Neil D Dolinski , Athina Anastasaki , Andy T Hsueh , H Tom Soh , Craig J Hawker

Affiliation

We report a simple procedure for rapid, visible light-mediated, controlled radical polymerization in aqueous solutions. Based on the photoelectron transfer reversible addition–fragmentation chain transfer (PET–RAFT) polymerization, fast chain propagation at room temperature in water was achieved in the presence of reductant and without prior deoxygenation. A systematic study correlating irradiation intensity and polymerization kinetics, enabled by in situ nuclear magnetic resonance spectroscopy, provided optimized reaction conditions. The versatility of this procedure was demonstrated through a rapid triblock copolymer synthesis, and incorporation of water-labile activated esters for direct conjugation of hydrophilic small molecules and proteins. In addition, this technique boasts excellent temporal control and provides a wide range of macromolecular materials with controlled molecular weights and narrow molecular weight distributions.

中文翻译：

具有原位监测的快速可见光介导的受控水相聚合

我们报告了一种在水溶液中快速、可见光介导、受控自由基聚合的简单程序。基于光电子转移可逆加成-断裂链转移（PET-RAFT）聚合，在存在还原剂且无需预先脱氧的情况下，在室温下在水中实现快速链增长。通过原位核磁共振光谱对辐照强度和聚合动力学进行系统研究，提供了优化的反应条件。该程序的多功能性通过快速三嵌段共聚物合成和掺入水不稳定的活性酯以直接缀合亲水性小分子和蛋白质来证明。此外，

更新日期：2017-09-22

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