The endophytic Trichoderma atroviridae UB-LMA was isolated as a symbiont of Taxus baccata and analyzed for its antimicrobial activity. By applying an original approach consisting of solid-state cultivation coupled with solid-phase extraction, a new methyl (R,E)-3-(1-hydroxy-4-oxocyclopent-2-en-1-yl)-acrylate derivative named EA-2801 (1) was isolated together with the previously reported isonitrin A and dermadin methyl ester. The chemical structure of 1 was determined by NMR and MS. Compound 1 showed antimicrobial activity against a panel of Gram-positive and -negative bacteria.

中文翻译：

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从木霉菌中分离出抗生素（R，E）-3-（1-羟基-4-氧代环戊-2-烯-1-基）丙烯酸甲酯EA-2801。

分离出内生的木霉黄萎病菌UB-LMA作为红豆杉的共生菌，并对其抗菌活性进行了分析。通过采用固态培养与固相萃取相结合的原始方法，新的（R，E）-3-（1-羟基-4-氧代环戊-2-烯-1-基）丙烯酸甲酯衍生物EA-2801（1）与先前报道的异亚硝酸盐A和皮肤素甲基酯一起被分离出来。1的化学结构通过NMR和MS确定。化合物1显示出对一组革兰氏阳性和阴性细菌的抗菌活性。