Siderophores are chemically diverse secondary metabolites that primarily assist the host organisms to chelate iron. Siderophores are biosynthesized by many biological organisms, including bacteria, fungi, and plants and they are responsible for a variety of biological functions beyond capture iron. Thus, they could provide a novel understanding of host‐pathogen interactions, plant physiology, disease pathogenesis, and drug development. However, knowledge gaps in analytical technologies, chemistry, and biology have severely impeded the applications of siderophores, and a new strategy is urgently needed to bridge these gaps. Mass spectrometry (MS) and associated technologies render unparalleled advantages in this niche in terms of high throughput, resolution, and sensitivity. Herein, this critical review briefly summarizes progress in the study of siderophores and specifically identifies MS‐based novel strategies that attempt to mimic the complexity of siderophore systems in order to increase the applicability of these compounds in the scientific community. © 2016 Wiley Periodicals, Inc. Mass Spec Rev 37:188–201, 2018.

中文翻译：

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质谱衍生的系统生物学技术描述了系统的铁载体的生化应用

铁载体是化学上多样化的次生代谢产物，主要帮助宿主生物螯合铁。铁载体是由许多生物有机体（包括细菌，真菌和植物）生物合成的，它们负责捕获铁以外的多种生物学功能。因此，它们可以提供对宿主-病原体相互作用，植物生理学，疾病发病机理和药物开发的新颖理解。但是，分析技术，化学和生物学领域的知识鸿沟严重阻碍了铁载体的应用，因此迫切需要一种新的策略来弥补这些鸿沟。质谱（MS）和相关技术在高产量，高分离度和高灵敏度方面在这一领域具有无与伦比的优势。在此处，这篇重要的评论简要总结了铁载体的研究进展，并特别指出了基于MS的新颖策略，这些策略试图模仿铁载体系统的复杂性，以提高这些化合物在科学界的适用性。©2016 Wiley Periodicals，Inc.质谱修订版37：188–201，2018年。