A wide array of cell-intrinsic surveillance mechanisms maintains the homeostasis of dividing cells and the integrity of the genome. Accumulating evidence also supports a role for cell-extrinsic mechanisms. Among them, the immune system, together with cell-autonomous checkpoint processes, eliminates cells that harbor unbalanced karyotypes generated by mitotic defects.

中文翻译：

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复杂核型恶性细胞的免疫监测

各种各样的细胞内在监视机制可维持分裂细胞的动态平衡和基因组的完整性。越来越多的证据也支持细胞外源性机制的作用。其中，免疫系统与细胞自主检查点过程一起，消除了具有有丝分裂缺陷所产生的不平衡核型的细胞。