Melanoma derived from melanocytes is the most aggressive genre of skin cancer. Although the considerable advancement in the study of human cancer biology and drug discovery, most advanced melanoma patients are inevitably unable to be cured. With the emergence of nanotechnology, the use of nano-carriers is widely expected to alter the landscape of melanoma treatment. In this review, we will discuss melanoma biology, current treatment options, mechanisms behind drug resistance, and nano-based solutions for effective anti-cancer therapy, followed by challenges and perspectives in both pre-clinical and clinical settings.

中文翻译：

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针对黑素瘤的靶向药物递送

源自黑素细胞的黑色素瘤是皮肤癌最具有侵略性的类型。尽管人类癌症生物学和药物发现研究取得了长足的进步，但大多数晚期黑素瘤患者不可避免地无法治愈。随着纳米技术的出现，人们广泛预期使用纳米载体将改变黑素瘤治疗的面貌。在这篇综述中，我们将讨论黑色素瘤生物学，当前的治疗选择，耐药性背后的机制以及有效的抗癌治疗的纳米解决方案，以及在临床前和临床环境中的挑战和前景。