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Stem Cells: Controlled Exposure of Bioactive Growth Factor in 3D Amyloid Hydrogel for Stem Cells Differentiation (Adv. Healthcare Mater. 18/2017)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2017-09-20 , DOI: 10.1002/adhm.201770094
Subhadeep Das 1, 2, 3 , Rakesh Kumar 2 , Narendra Nath Jha 2 , Samir K. Maji 2
Affiliation  

Samir K. Maji and co‐workers present an amyloid hydrogel for sustained growth factors delivery in tissue engineering applications in article number 1700368. The image represents stem cells (blue spheres) embedded within the amyloid hydrogel matrix (grey network) encapsulating growth factors (green dots). Within 3D culture, stem cells self‐organizes into spheroids (red sphere) with up‐regulated neural genes. In three‐dimensional cell culture, the entrapped growth factors within hydrogel and the surface property of amyloids promoted stem cells into neuro‐sphere formation and higher neuronal gene expression.
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中文翻译:

干细胞:用于干细胞分化的3D淀粉样蛋白水凝胶中生物活性生长因子的受控暴露(Adv。Healthcare Mater。18/2017)

Samir K. Maji和他的同事在编号1700368的组织工程应用中提出了一种淀粉样蛋白水凝胶,用于持续生长因子的递送。该图像表示包埋在淀粉样蛋白水凝胶基质(灰色网络)中的干细胞(蓝色球),其包裹了生长因子(绿色)。点)。在3D培养中,干细胞会自组织成具有上调的神经基因的球体(红球)。在三维细胞培养中,水凝胶中截留的生长因子和淀粉样蛋白的表面特性促进干细胞进入神经球形成和更高的神经元基因表达。
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更新日期:2017-09-20
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