Genome mining reveals a new ribosomally synthesized and post-translationally modified peptide (RiPP) from Klebsiella pneumoniae. This new antibiotic inhibits bacterial ribosomes by obstructing the peptide exit tunnel, and its modular nature presents a unique opportunity for future engineering of antibacterial drugs.

中文翻译：

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基因组采矿：挖掘化学空间的隧道

基因组挖掘揭示了肺炎克雷伯菌的一种新的核糖体合成和翻译后修饰的肽（RiPP）。这种新的抗生素通过阻塞肽出口通道来抑制细菌核糖体，其模块化性质为抗菌药物的未来工程化提供了独特的机会。