Rapid Turn-On Fluorescence Detection of Copper(II): Aromatic Substituent Effects on the Response Rate,Organic Process Research & Development

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Rapid Turn-On Fluorescence Detection of Copper(II): Aromatic Substituent Effects on the Response Rate
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2017-09-15 00:00:00 , DOI: 10.1021/acs.oprd.7b00269
Jiyoung Jung ₁ , Junyong Jo ₂ , Adriana Dinescu ₃

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Oxidative cyclization of o-phenylazo aniline was utilized as a turn-on fluorescent probe of the copper(II) ion. The number and the position of electron donating groups on the probes were systematically varied to investigate the effect of aryl substituent on reactivity toward copper ion. Among the series of analogous probes, the 2,4,6-trimethoxy substituted probe exhibits not only a faster (40-times faster) reaction but also a lower detection limit (20 times lower) than previously reported probes under identical conditions. The comparative kinetic studies reveal that both the number and the position of substitution have a significant impact on the reactivity toward copper, which will be discussed in the manuscript.

中文翻译：

铜（II）的快速开启荧光检测：芳香取代基对响应率的影响

邻苯基偶氮苯胺的氧化环化被用作铜（II）离子的开启荧光探针。系统地改变探针上给电子基团的数目和位置，以研究芳基取代基对铜离子反应性的影响。在一系列类似的探针中，与之前报道的相同条件下的探针相比，2,4,6-三甲氧基取代的探针不仅显示出更快的反应速度（快40倍），而且检测限更低（降低了20倍）。对比动力学研究表明，取代的数量和位置都对铜的反应性有重要影响，这将在手稿中进行讨论。

更新日期：2017-09-15

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