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Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2017-09-11 , DOI: 10.1038/nchembio.2471 Tristan de Rond 1 , Parker Stow 1 , Ian Eigl 2 , Rebecca E Johnson 1 , Leanne Jade G Chan 3, 4 , Garima Goyal 3, 4 , Edward E K Baidoo 3, 4 , Nathan J Hillson 3, 4, 5 , Christopher J Petzold 3, 4 , Richmond Sarpong 1 , Jay D Keasling 2, 3, 4, 6, 7
中文翻译：
烷基甘油单加氧酶样酶对灵菌红的氧化环化
更新日期：2017-09-12
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2017-09-11 , DOI: 10.1038/nchembio.2471 Tristan de Rond 1 , Parker Stow 1 , Ian Eigl 2 , Rebecca E Johnson 1 , Leanne Jade G Chan 3, 4 , Garima Goyal 3, 4 , Edward E K Baidoo 3, 4 , Nathan J Hillson 3, 4, 5 , Christopher J Petzold 3, 4 , Richmond Sarpong 1 , Jay D Keasling 2, 3, 4, 6, 7
Affiliation
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Prodiginines, which are tripyrrole alkaloids displaying a wide array of bioactivities, occur as linear and cyclic congeners. Identification of an unclustered biosynthetic gene led to the discovery of the enzyme responsible for catalyzing the regiospecific C–H activation and cyclization of prodigiosin to cycloprodigiosin in Pseudoalteromonas rubra. This enzyme is related to alkylglycerol monooxygenase and unrelated to RedG, the Rieske oxygenase that produces cyclized prodiginines in Streptomyces, implying convergent evolution.
中文翻译：
烷基甘油单加氧酶样酶对灵菌红的氧化环化
Prodiginines 是一种具有多种生物活性的三吡咯生物碱，以线性和环状同系物的形式存在。一个非簇生物合成基因的鉴定导致了在红色假交替单胞菌中负责催化区域特异性 C-H 激活和灵菌红环化为环灵菌红的酶的发现。该酶与烷基甘油单加氧酶有关，与 RedG 无关，RedG 是链霉菌中产生环化 prodiginines 的 Rieske 加氧酶，这意味着趋同进化。
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