Prodiginines, which are tripyrrole alkaloids displaying a wide array of bioactivities, occur as linear and cyclic congeners. Identification of an unclustered biosynthetic gene led to the discovery of the enzyme responsible for catalyzing the regiospecific C–H activation and cyclization of prodigiosin to cycloprodigiosin in Pseudoalteromonas rubra. This enzyme is related to alkylglycerol monooxygenase and unrelated to RedG, the Rieske oxygenase that produces cyclized prodiginines in Streptomyces, implying convergent evolution.

中文翻译：

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烷基甘油单加氧酶样酶对原黄酮的氧化环化

Prodiginines是显示出广泛生物活性的三吡咯生物碱，以线性和环状同源物形式出现。鉴定未聚簇的生物合成基因导致发现了一种酶，该酶可在红假单胞菌中催化区域特异性C–H活化和原黄酮的环化成环原黄菌素。该酶与烷基甘油单加氧酶有关，与RedG（Rieske加氧酶）无关，Rieske加氧酶在链霉菌中产生环糊精，意味着会聚。