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Copper Acquisition and Utilization in Fungi
Annual Review of Microbiology ( IF 8.5 ) Pub Date : 2017-09-08 00:00:00 , DOI: 10.1146/annurev-micro-030117-020444
Aaron D. Smith 1 , Brandon L. Logeman 1 , Dennis J. Thiele 1, 2, 3
Affiliation  

Fungal cells colonize and proliferate in distinct niches, from soil and plants to diverse tissues in human hosts. Consequently, fungi are challenged with the goal of obtaining nutrients while simultaneously elaborating robust regulatory mechanisms to cope with a range of availability of nutrients, from scarcity to excess. Copper is essential for life but also potentially toxic. In this review we describe the sophisticated homeostatic mechanisms by which fungi acquire, utilize, and control this biochemically versatile trace element. Fungal pathogens, which can occupy distinct host tissues that have their own intrinsic requirements for copper homeostasis, have evolved mechanisms to acquire copper to successfully colonize the host, disseminate to other tissues, and combat host copper bombardment mechanisms that would otherwise mitigate virulence.

中文翻译:


真菌中铜的获取与利用

真菌细胞在不同的生态位中定居并增殖,从土壤和植物到人类宿主的各种组织。因此,真菌面临着获取营养物的挑战,同时要制定健全的调节机制以应对从稀缺到过量的各种营养物的可用性。铜对于生命至关重要,但也可能具有毒性。在这篇综述中,我们描述了真菌获取,利用和控制这种生物化学通用微量元素的复杂的稳态机制。真菌病原体可以占据对铜稳态具有内在要求的独特宿主组织,它们已经进化出机制来获取铜,以成功地定居于宿主,传播到其他组织,并与宿主铜轰击机制进行斗争,否则该机制会减轻毒力。

更新日期:2017-09-08
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