Oligoprolines as Molecular Entities for Controlling Distance in Biological and Material Sciences,Accounts of Chemical Research

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Oligoprolines as Molecular Entities for Controlling Distance in Biological and Material Sciences
Accounts of Chemical Research ( IF 16.4 ) Pub Date : 2017-09-08 00:00:00 , DOI: 10.1021/acs.accounts.7b00340
Stefanie Dobitz ₁ , Matthew R. Aronoff ₁ , Helma Wennemers ₁

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Nature utilizes large biomolecules to fulfill tasks that require spatially well-defined arrangements at the molecular level such as electron transfer, ligand–receptor interactions, or catalysis. The creation of synthetic molecules that enable precise control over spacing and functionalization provides opportunities across diverse disciplines. Key requirements of functionalizable oligomeric scaffolds include the specific control of their molecular properties where the correct balance of flexibility and rigidity must be maintained in addition to the prerequisite of defined length. These molecules must ideally be equally applicable in aqueous and organic environments, they must be easy to synthesize in a controlled stepwise fashion, and they must be easily modified with a palette of chemical appendages having diverse functionalities.

中文翻译：

寡脯氨酸作为控制生物和材料科学中距离的分子实体

大自然利用大型生物分子来完成需要在分子水平上在空间上明确定义的排列的任务，例如电子转移，配体-受体相互作用或催化作用。能够精确控制间距和功能化的合成分子的产生为不同学科提供了机会。可官能化的低聚物支架的关键要求包括对其分子特性的特定控制，除了确定长度的前提外，还必须保持柔韧性和刚性的正确平衡。这些分子在理想情况下必须同样适用于水性和有机环境，它们必须易于以受控的逐步方式进行合成，并且必须使用具有多种功能的化学附件调色板轻松地对其进行修饰。

更新日期：2017-09-08

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