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Mediators of mutualistic microbe–microbe interactions
Natural Product Reports ( IF 10.2 ) Pub Date : 2017-09-08 00:00:00 , DOI: 10.1039/c7np00035a
Kirstin Scherlach 1, 2, 3, 4, 5 , Christian Hertweck 1, 2, 3, 4, 5
Affiliation  

The co-existence of different microbial species in one habitat is prerequisite for many ecosystem processes. To facilitate co-habitation of ecological niches, intricate mechanisms have evolved that regulate the growth and the behaviour of microbes. A crucial aspect for the establishment and maintenance of a microbial population is the communication among species. Whereas intraspecies communication processes have been widely studied, little is known about the molecular mechanisms underlying interspecies interactions. Through the advance of modern analytical and sequencing technologies, we are now beginning to gain deeper insights into these complex processes. A key feature of microbe–microbe interaction is the secretion of chemical mediators to influence either the microbial partner or co-occurring higher organisms to shape the specific microenvironment. Here we summarize recent advances in understanding the role of natural products as regulators of microbial interaction in various ecological niches. Special attention is paid to mutualistic relationships with relevance for ecology and agriculture as well as medicine.

中文翻译:

微生物间相互作用的中介者

一个生境中不同微生物物种的共存是许多生态系统过程的前提。为了促进生态位的共同栖息,已经形成了调控微生物的生长和行为的复杂机制。建立和维持微生物种群的关键方面是物种之间的交流。尽管种间交流过程已得到广泛研究,但对种间相互作用的分子机制了解甚少。通过现代分析和测序技术的发展,我们现在开始对这些复杂的过程获得更深刻的见解。微生物与微生物相互作用的一个关键特征是化学介质的分泌会影响微生物伴侣或共同存在的高级生物,从而形成特定的微生物环境。在这里,我们总结了在理解天然产物在各种生态位中作为微生物相互作用调节剂的作用方面的最新进展。特别注意与生态,农业以及医学有关的相互关系。
更新日期:2017-09-08
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