Asthma is a complex disease of the airways that develops as a consequence of both genetic and environmental factors. This interaction has highlighted genes important in early life, particularly those that control lung development, such as the Wingless/Integrase-1 (WNT) signalling pathway. Although aberrant WNT signalling is involved with an array of human conditions, it has received little attention within the context of asthma. Yet it is highly relevant, driving events involved with inflammation, airway remodelling, and airway hyper-responsiveness (AHR). In this review, we revisit asthma therapeutics by examining whether WNT signalling is a valid therapeutic target for asthma.

哮喘是一种复杂的呼吸道疾病，是遗传和环境因素共同作用的结果。这种相互作用突出了早期生命中重要的基因，尤其是那些控制肺部发育的基因，例如Wingless / Integrase-1（WNT）信号传导途径。尽管异常的WNT信号传导与一系列人类疾病有关，但是在哮喘的背景下，它却鲜有受到关注。然而，它与炎症，气道重塑和气道高反应性（AHR）有关的驾驶事件具有高度相关性。在这篇综述中，我们通过检查WNT信号传导是否是哮喘的有效治疗靶点来重新研究哮喘治疗方法。