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Weaving for heart valve tissue engineering
Biotechnology Advances ( IF 16.0 ) Pub Date : 2017-08-04 , DOI: 10.1016/j.biotechadv.2017.07.012
Albert Liberski , Nadia Ayad , Dorota Wojciechowska , Radoslaw Kot , Duy M.P. Vo , Dilibaier Aibibu , Gerald Hoffmann , Chokri Cherif , Katharina Grobelny-Mayer , Marek Snycerski , Helmut Goldmann

Weaving is a resourceful technology which offers a large selection of solutions that are readily adaptable for tissue engineering (TE) of artificial heart valves (HV). The different ways that the yarns are interlaced in this technique could be used to produce complex architectures, such as the three-layer architecture of the leaflets. Once the assembly is complete, growth of cells in the scaffold would occur in the orientation of the yarn, enabling the deposition of extra cellular matrixes proteins in an oriented manner. Weaving technology is a rapidly evolving field that, first, needs to be understood, and then explored by tissue engineers, so that it could be used to create efficient scaffolds. Similarly, the textile engineers need to gain a basic understanding of key structural and mechanical aspects of the heart valve. The aim of this review is to provide the platform for joining these two fields and to enable cooperative research efforts. Moreover, examples of woven medical products and patents as well as related publication are discussed in this review, nevertheless due to the large, and continuously growing volume of data, only the aspects strictly associated with HVTE lay in the scope of this paper.



中文翻译:

心脏瓣膜组织工程编织

编织是一项资源丰富的技术,可提供多种解决方案选择,这些解决方案很容易适用于人造心脏瓣膜(HV)的组织工程(TE)。这种技术中纱线交织的不同方式可用于产生复杂的结构,例如小叶的三层结构。一旦组装完成,支架中细胞的生长将在纱线的方向上发生,从而能够以定向的方式沉积额外的细胞基质蛋白。编织技术是一个快速发展的领域,首先需要了解,然后由组织工程师进行探索,以便可以将其用于创建高效的支架。同样,纺织工程师需要对心脏瓣膜的关键结构和机械方面有基本的了解。这篇综述的目的是为加入这两个领域提供平台并促进合作研究工作。此外,在这篇综述中讨论了编织医疗产品和专利的例子以及相关出版物,但是由于数据量巨大且持续增长,只有与HVTE严格相关的方面才属于本文的范围。

更新日期:2017-08-04
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